%0 Journal Article
%4 sid.inpe.br/mtc-m21b/2017/04.19.16.27
%2 sid.inpe.br/mtc-m21b/2017/04.19.16.27.59
%@doi 10.1007/s10008-016-3451-9
%@issn 1432-8488
%T Evaluation of a novel composite based on functionalized multi-walled carbon nanotube and iron phthalocyanine for electroanalytical determination of isoniazid
%D 2017
%8 Apr.
%9 journal article
%A Spindola, Rolff Ferreira,
%A Zanin, Hudson,
%A Macena, Cleidivan Silva,
%A Contin, André,
%A Luz, Rita de Cássia Silva,
%A Damos, Flávio Santos,
%@affiliation Universidade Federal do Maranhão (UFMA)
%@affiliation Universidade Estadual de Campinas (UNICAMP)
%@affiliation Universidade Federal do Maranhão (UFMA)
%@affiliation Instituto Nacional de Pesquisas Espaciais (INPE)
%@affiliation Universidade Federal do Maranhão (UFMA)
%@affiliation Universidade Federal do Maranhão (UFMA)
%@electronicmailaddress
%@electronicmailaddress
%@electronicmailaddress
%@electronicmailaddress andre.contin@las.inpe.br
%@electronicmailaddress
%@electronicmailaddress flavio.damos@ufma.br
%B Journal of Solid State Electrochemistry
%V 21
%N 4
%P 1089-1099
%K Graphene oxide, Iron phthalocyanine, Isoniazid, Multi-walled carbon nanotube oxide.
%X A novel platform for electroanalysis of isoniazid based on graphene-functionalized multi-walled carbon nanotube as support for iron phthalocyanine (FePc/f-MWCNT) has been developed. The FePc/f-MWCNT composite has been dropped on glassy carbon forming FePc/f-MWCNT/GC electrode, which is sensible for isoniazid, decreasing substantially its oxidation potential to +200 mV vs Ag/AgCl. Electrochemical and electroanalytical properties of the FePc/f-MWCNT/GC-modified electrode were investigated by cyclic voltammetry, electrochemical impedance spectroscopy, scanning electrochemical microscopy, and amperometry. The sensor presents better performance in 0.1 mol L−1 phosphate buffer at pH 7.4. Under optimized conditions, a linear response range from 5 to 476 μmol L−1 was obtained with a limit of detection and sensitivity of 0.56 μmol L−1 and 0.023 μA L μmol−1, respectively. The relative standard deviation for 10 determinations of 100 μmol L−1 isoniazid was 2.5%. The sensor was successfully applied for isoniazid selective determination in simulated body fluids.
%@language en
%3 spindola_evaluation.pdf